Working model illustrating how HDAC3 deacetylase activity regulates major ZGA gene expression through histone acetylation reprogramming and chromatin accessibility. (IMAGE)
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Under normal conditions, HDAC3 deacetylase activity coordinates histone acetylation reprogramming and chromatin accessibility during major ZGA, thereby ensuring the proper activation of major ZGA genes and normal preimplantation embryonic development. Conversely, loss of HDAC3 deacetylase activity disrupts these epigenetic processes, leading to widespread dysregulation of major ZGA genes and ultimately resulting in developmental arrest.
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