Model illustrating lncCtxnd1-dependent regulation and function in the tumor microenvironment (IMAGE)
Caption
Top: in lncCtxnd1 wild‑type tumors, N‑terminal CTXND1 peptide promotes pro‑inflammatory TAM polarization (blue cells). CTXND1 N‑terminal activity suppresses mTORC1 in TAMs, is associated with decreased expression of Arg1, Cd206, ApoE and Tgfb, and increased MHC‑I presentation, resulting in enhanced CD8+ T cell cytotoxicity and tumor regression.
Bottom: in lncCtxnd1‑deficient tumors, TAMs adopt an anti‑inflammatory phenotype (purple cells) with elevated Arg1, Cd206, ApoE and Tgfb and reduced MHC‑I, leading to impaired CD8+ T cell function and tumor progression. Color legend: pro‑inflammatory TAM (light blue), anti‑inflammatory TAM (purple), tumor cell (red), CD8+ T cell (gray/sea green).
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