Understanding YAP-1-TEAD-TET1-Mediated Epigenetic Regulation in DGM-Negative Cancers (IMAGE)

Institute of Science Tokyo

Understanding YAP-1-TEAD-TET1-Mediated Epigenetic Regulation in DGM-Negative Cancers

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Researchers at Institute of Science Tokyo have uncovered a novel YAP1–TEAD–TET1 epigenetic pathway that drives hepatocellular carcinoma without canonical driver gene mutations. By revealing how TET1-mediated DNA demethylation activates multiple oncogenes, the findings offer new insights into cancer development beyond conventional mutation-driven mechanisms.

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Institute of Science Tokyo

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