Shifting Additional Densities in ubiB-Treated Pathological Tau Filaments (IMAGE)
Caption
Reconstructed cryo-EM density maps and refined atomic model overlays of VT Ia tau filaments from untreated (left) and ubistatin B (ubiB)-treated (right) preparations derived from vacuolar tauopathy brain tissue. In the ubiB-treated preparation, additional densities shift toward positively charged tau residues (shown in blue), as marked by yellow plus signs. Bottom panels show enlarged views of the boxed regions in the corresponding top panels.
Credit
Ryohei Watanabe et al.
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CC BY-NC-ND