Integration of photobiomodulation and nanomedicine: Recent advances and possible mechanisms for non-photoactive nanoparticles (IMAGE)
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Photobiomodulation (PBM), which involves the application of low-intensity light to modulate cellular and biomolecular activities, has demonstrated substantial therapeutic potential in various clinical applications. In contrast, nanoparticles (NPs) are increasingly being utilized in the biomedical field as therapeutic and diagnostic agents. Despite the individual advantages of each approach, their combination is rarely reported, and the possibility of synergistic effects that may arise from their integration remains unexplored. This review provides a brief analysis of the limited literature available on this novel approach, followed by a specific focus on the mechanistic pathways underlying NP internalization and the potential impact of PBM. Specifically, we explore the cellular and molecular processes by which PBM can influence NP-cell interaction, particularly through alterations in endocytic pathways and intracellular trafficking. The review concludes by addressing the current challenges, identifying key research gaps, and outlining the future potential of combining PBM and NPs for advancing targeted nanotherapeutic strategies.
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Shenzhen University
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