Proposed model of MsMTA-mediated m⁶A regulation in alfalfa. (IMAGE)

Nanjing Agricultural University The Academy of Science

Proposed model of MsMTA-mediated m⁶A regulation in alfalfa.

Caption

Proposed model of MsMTA-mediated m⁶A regulation in alfalfa. MsMTA functions as an m⁶A methyltransferase that deposits m⁶A marks on mRNAs involved in redox metabolism (MsSDR1, MsLOX3), small-molecule metabolism (MsSCPL22, MsATPC2), and organonitrogen biosynthesis (MsGS2, MsAPT1). ALKBH, an m⁶A demethylase, removes m⁶A marks from these mRNAs, regulating their stability and associated metabolic pathways. Silencing of MsMTA decreases overall m⁶A methylation levels, leading to reduced mRNA stability of these genes and the downregulation of associated metabolic pathways. Consequently, MsMTA deficiency disrupts energy metabolism and carbon–nitrogen balance, resulting in shortened internodes and reduced plant height in M. sativa.

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Horticulture Research

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