Challenges and solutions for in vivo CAR-T cell therapy (IMAGE)
Caption
Schematic representation of the current challenges and possible solutions for in vivo chimeric antigen receptor T cells (CAR-T) development in the following three aspects: the persistence limitation of mRNA-based in vivo CAR-T, on-target and off-target-mediated adverse effects, and immunogenicity associated with redosing in vivo CAR-T vectors. The illustrations were created through biorender.com
Credit
Professor Huji Xu from Naval Medical University, China; Professor Xuanming Yang and Professor Yujia Cai from Shanghai Jiao Tong University, China Image source link: https://link.springer.com/article/10.1007/s44466-026-00050-4
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License
CC BY-NC-ND