Genetic risk shifts waist-to-height ratio cutoffs, but screening performance stays strong. (IMAGE)

Zhejiang University

Genetic risk shifts waist-to-height ratio cutoffs, but screening performance stays strong.

Caption

Genetic risk shifts waist-to-height ratio cutoffs, but screening performance stays strong. Relationship between genetic risk score (GRS) Z‑score and the optimal waist‑to‑height ratio (WHtR) cutoff for detecting pediatric metabolic dysfunction‑associated steatotic liver disease (MASLD). As GRS increases (indicating higher inherited susceptibility), the recommended WHtR threshold decreases slightly, but the overall discrimination performance, measured by the area under the receiver operating characteristic curve (AUC), remains consistently high. This pattern demonstrates that while genetic burden modestly influences the theoretical cutoff, the WHtR retains its robust and practical screening utility across a wide range of genetic backgrounds.

Credit

World Journal of Pediatrics

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