BRD4 Structure (IMAGE)
Caption
Two views of the cryo-electron microscopy structure of BRD4, a protein that binds to chromosomes to turn on or off the expression of other genes and has been linked to various cancers, in complex with a nucleosome, a part of the chromosome's structure. The new structure confirms that the protein’s bromodomain (pink) binds to a chemically modified animo acid (acetyl lysine, blue) on histone H4 (green), but further experiments show it binds nearly as well to unmodified histones.
Credit
Song Tan, Penn State
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CC BY-NC-ND