Evaluation of peroxidation activity and tumor therapy. (IMAGE)

Science China Press

Evaluation of peroxidation activity and tumor therapy.

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(a) UV-Vis absorbance at 420 nm. Steady-state kinetic assay for (b) Fe@MFI and (c) Fe/MFI. Insets show double-reciprocal plots of activities. (d) Intracellular ROS levels in CT26 cells. (e) Cell viability of CT26 cells following incubation with Fe3O4 NPs, Fe/MFI, and Fe@MFI at different concentrations (n = 6). (f) Calcein-AM/PI co-staining images of CT26 cells. (g) Scheme of the experiment schedule. (h) Tumor volume growth curves for different treatment groups (n = 5). Photographs of (i) resected tumors and (j) tumor weights after different treatments (n = 5). (k) Body weight curves of mice after different treatments (n = 5). Data are presented as mean ± SD. The P-values were calculated using one-way ANOVA. *P < 0.05, ***P < 0.001, ****P < 0.0001.

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