Model for mitotic chromosome formation (IMAGE)

Research Organization of Information and Systems

Model for mitotic chromosome formation

Caption

Model for mitotic chromosome formation. In interphase nuclei, chromatin is broadly divided into active euchromatic regions (red) and transcriptionally inactive heterochromatic regions (blue), but both exist as condensed chromatin domains. During mitosis, these pre-existing chromatin domains, used as “building blocks,” may be gathered, crosslinked, and reorganized by condensins, topoisomerase IIα, electrostatic interactions, free Mg2+, depletion attraction, and other factors to form mitotic chromosomes.

Credit

Sachiko Tamura, Kazuhiro Maeshima

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