Biomimetic PD‑1‑Functionalized Immunostimulatory Nanomedicine Enables STING Activation and Durable Antitumor Immunity in Hepatocellular Carcinoma (IMAGE)
Caption
- Clinical cohort analyses identify stimulator of interferon genes (STING) signaling as a key determinant of immune responsiveness in hepatocellular carcinoma (HCC), providing a data-driven rationale for nanomedicine design.
- A carrier-free coordination nanomedicine co-assembles MSA-2 and indocyanine green to couple photothermal-induced immunogenic cell death with STING activation, while PD-1 membrane camouflage enables ~fivefold tumor accumulation and localized checkpoint blockade.
- This integrated strategy converts immune-cold HCC into an immune-active state, achieving durable tumor control and systemic immune memory against metastasis.
Credit
Yanbing Cao, Xinyi Lin*, Bingchen Wu, Yang Li, Wenrui Zhu, Binxin Liu, Aixian Zheng, Lingjie Wu, Yanyang Wang*, Xiaolong Liu*, Ming Wu*.
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CC BY-NC-ND