Schematic overview and study design of the ULM-based Vascular Biomarker Automated Analysis (U-VBA) framework (IMAGE)

BMEF (BME Frontiers)

Schematic overview and study design of the ULM-based Vascular Biomarker Automated Analysis (U-VBA) framework

Caption

A preclinical rabbit model undergoing longitudinal ocular vascular monitoring before and after induced optic nerve injury (upper panel) and a clinical cohort including patients with cervical lymph nodes of different pathological types (bottom panel) were used to demonstrate the generalizability of the framework. The experimental procedures for both studies include ultrasound data acquisition and reconstruction, extraction and analysis of vascular biomarkers, and construction of diagnostic models. The hierarchical edge-bundling diagram (right) illustrates relationships among ocular biomarkers. Each circular leaf node represents a specific biomarker measured in a particular vascular structure. Node size is proportional to the magnitude of the statistically significant difference observed for that biomarker in this study; larger nodes indicate a greater statistically significant difference.

Credit

XUEJUN Lab@ShanghaiTech

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