Synthetic bacterium-based glucan nanofilm vaccine enhances antifungal immune protection (IMAGE)

Tsinghua University Press

Synthetic bacterium-based glucan nanofilm vaccine enhances antifungal immune protection

Caption

Engineered E. coli cells assemble glucan nanofilms on their surfaces and display fungal antigen candidalysin to generate an antifungal vaccine. Following vaccination, the engineered bacteria activate Dectin-1-mediated innate immune responses, promote dendritic cell maturation and T cell activation, and enhance pathogen clearance during systemic Candida albicans infection.

Credit

Qilin Yu Laboratory, Nankai University

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