IrMn‑Cluster‑Based Artificial Metalloenzymes with Radiosensitized Systemic Antitumor Responses to Prevent Malignant Tumor Metastasis and Recurrence (IMAGE)
Caption
- The bioinspired design of IrMn-based redox centers (IMM) with rapid electron transfer can promote the formation of electron-rich IMM, thereby guaranteeing superior radio-enhanced reactive oxygen species biocatalysis and O2 generation.
- The tumor-adaptive and biocompatible IMM can induce mitochondrial dysfunction and hinder DNA repair, resulting in robust immunogenic cell death.
- An IMM-based biocatalyst can activate systemic antitumor responses and reverse a suppressive tumor microenvironment, thereby boosting tumoricidal effects and preventing metastasis and recurrence by synergizing with checkpoint blockade therapy.
Credit
Ruidan Li, Qinlong Wen, Zhenyu Xing, Ting Wang, Jing Yang, Yunfeng Tao, Shengdong Mu, Shuang Li, Zhigong Wei, Chong Cheng*, Xingchen Peng*.
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License
CC BY-NC-ND