Efficient Mucosal Penetration and Local Immune Activation by a Broad-Spectrum Gold Nanovaccine Platform (IMAGE)

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Efficient Mucosal Penetration and Local Immune Activation by a Broad-Spectrum Gold Nanovaccine Platform

Caption

Size-optimized AuNPs enhance mucosal delivery through high-density antigen display while focusing germinal center B cell responses specifically on target antigens rather than the carrier. Intranasal AuNP-RBD vaccination establishes robust mucosal and systemic dual-layer immunity. Furthermore, mosaic AuNPs co-displaying six representative RBDs confer broad cross-protection against diverse sarbecoviruses and merbecoviruses.

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hLife

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