Comprehensive metabolomic analysis reveals distinct plasma profiles in patients with BCD (IMAGE)
Caption
(a) OPLS-DA score plot demonstrating clear separation between groups (R2Y = 84.6%, Q2 = 82.4%). (b) Cross-validation prediction errors (PRESS) across seven folds, with values below 0.6 indicating model stability. Permutation test results show that R2Y values remained above 0.75 throughout all folds, confirming the robustness of the model against overfitting. (c) Volcano plot showing differential metabolite expression between patients with BCD (n = 36) and controls (n = 49). Red and blue dots represent significantly up- and downregulated metabolites, respectively (FDR < 0.05, |log2FC| > 0.585). (d) Heatmap of the most significantly altered metabolites across all samples. The color scale indicates Z-score-normalized expression levels.
Credit
Yingke Zhao
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CC BY-NC