Diagram illustrating the primary pathological processes associated with sarcopenia linked to circadian rhythm mechanisms (IMAGE)
Caption
Clock genes regulate key processes involved in the development of sarcopenia, including muscle protein metabolism, neuromuscular junction abnormalities, mitochondrial dysfunction, impaired muscle insulin signaling, dysregulated autophagy, cellular senescence, and systemic chronic low-grade inflammation. These processes are influenced by the circadian clock, which coordinates molecular and cellular responses to environmental and internal cues. Given their involvement in these mechanisms, clock genes represent potential therapeutic targets for combating age-related muscle loss and associated conditions.Image Credit:
License Type: CC BY-NC-ND 4.0
Credit
Professor Tiantian Wang and Dr. Zhen Hong from West China Hospital of Sichuan University, China | Image Source Link: https://doi.org/10.1097/CM9.0000000000004087
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CC BY-NC-ND