Patient-Specific "Blood–Brain Tumor Barrier Chip" Predicts How Glioblastoma Patients Will Respond to Treatment (IMAGE)
Caption
Figure 1. The upper-left schematic shows the structure of a microfluidic chip designed to recreate the glioblastoma margin. Brain endothelial cells (HBMECs) in the upper vascular channel are co-cultured with astrocytes and patient-derived glioblastoma cells in the lower tissue channel. The fluorescence images compare healthy blood-brain barrier (BBB) with blood-brain tumor barrier model and graphs in the lower-left compare barrier permeability, electrical resistance, gene expression level, and anticancer drug responses between BBB and patient-specific blood-brain tumor barrier models (BBTB-A, B, and C). The right panel presents MRI scans from three patients with the same IDH-wildtype and MGMT-methylated status, together with their on-chip barrier function and drug responses and actual clinical outcomes, including progression-free survival (PFS) and post-progression survival (PPS). The close agreement between the on-chip results and the patients’ clinical courses demonstrates the model’s potential to predict patient-specific treatment responses.
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