Chronic Environmental Stress Drives Immune Maladaptation in Cold Tumors (IMAGE)

Pusan National University

Chronic Environmental Stress Drives Immune Maladaptation in Cold Tumors

Caption

Long-term environmental and metabolic stress sustain activation of the GDF15–IDO1–kynurenine–AhR pathway, reprogramming natural killer cells into a maladaptive exhausted state that promotes immune escape in cold tumors. 

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Pusan National University

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