Coral-Inspired immunoreprogramming scaffold promotes angiogenesis and bone regeneration (IMAGE)

Editorial Office of West China School of Stomatology, Sichuan University

Coral-Inspired immunoreprogramming scaffold promotes angiogenesis and bone regeneration

Caption

A coral-inspired, 3D-printed scaffold composed of multi-walled carbon nanotubes and nano-hydroxyapatite reprograms macrophages from a pro-inflammatory (M1) to a reparative (M2) state through activation of the PI3K-AKT signaling pathway. By creating a pro-regenerative immune microenvironment, the scaffold enhances angiogenesis and osteogenesis, ultimately promoting bone regeneration and recovery in a rabbit model of steroid-induced osteonecrosis of the femoral head. 

Credit

Dr. Yan Xiong from Army Medical University (Third Military Medical University), China, and Dr. Meng Tian and Dr. Pengde Kang from Sichuan University, China Image source link: https://www.nature.com/articles/s41413-026-00557-x

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License

CC BY

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