Cryo-EM structure of PFKL in complex with XJ-4-85 (IMAGE)

University of Texas at Austin

Cryo-EM structure of PFKL in complex with XJ-4-85 — Caption

PFKL is an enzyme in cancer cells that metabolizes sugar. This image shows the protein structure of PFKL bound to two parts of the experimental cancer drug XJ-4-85 (blue and orange). When XJ-4-85 binds the sites K677 and K315 on PFKL (inset), it boosts sugar metabolism and releases a payload (not shown) that shuts down fatty acid metabolism.

Credit

Eric Lynch (University of Washington) and Xiaoding Jiang (University of Texas at Austin).

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