Uncovering the immune mechanism behind the atopic march (IMAGE)

Tokyo University of Science

Uncovering the immune mechanism behind the atopic march

Caption

The study identified cDC2 dendritic cells as the critical immune cells through which IL-13 links allergic inflammation in the skin to severe allergic reactions throughout the body. By licensing these cells, IL-13 promotes the production of high-affinity IgE antibodies that can trigger anaphylaxis. 

Credit

Professor Emeritus Masato Kubo from Tokyo University of Science

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