Molecular pathway linking Kdf1 mutation to defective enamel formation (IMAGE)

Editorial Office of West China School of Stomatology, Sichuan University

Molecular pathway linking Kdf1 mutation to defective enamel formation

Caption

Researchers showed that a Kdf1 mutation disrupts cell-adhesion complexes in enamel-forming cells, alters Hippo pathway regulation, and increases nuclear YAP activity, leading to abnormal ameloblast behavior and defective enamel formation.

Credit

Image credit: Professor Dongsheng Yu and Professor Wei Zhao from Sun Yat-sen University, China Image source link: https://doi.org/10.1038/s41368-026-00445-4

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