AI-designed Notch activator C3-DLL4 induces ameloblast maturation. (IMAGE)

Editorial Office of West China School of Stomatology, Sichuan University

AI-designed Notch activator C3-DLL4 induces ameloblast maturation.

Caption

This study identified Notch signaling as a central driver of human ameloblast maturation and demonstrates that engineered pathway activation can replace odontoblast-derived signals to generate functional enamel-forming cells thereby providing a framework for enamel regeneration. These findings represent a significant step toward biologically based dental repair strategies. 

Credit

Professor Hannele Ruohola-Baker and Anjali P. Patni from the University of Washington Image source link: https://www.nature.com/articles/s41368-026-00429-4/figures/2

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