Axl–Erk1/2–Isg15 Signaling in Osteoblast Differentiation (IMAGE)

Editorial Office of West China School of Stomatology, Sichuan University

Axl–Erk1/2–Isg15 Signaling in Osteoblast Differentiation

Caption

The study suggests that AXL receptor tyrosine kinase (Axl) acts as a negative regulator of osteoblast differentiation by suppressing Erk1/2 phosphorylation and reducing Isg15 expression. Blocking Axl may reverse these effects, promoting bone formation and increasing bone mass in preclinical models.

Credit

Dr. Mubashir Ahmad, Dr. Anita Ignatius, and Dr. Jan Tuckermann from Ulm University, Germany Image source link: https://www.nature.com/articles/s41413-026-00554-0

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