KAIST Identifies a Molecular “Switch” That Activates Cell Growth Signaling, Suggesting a Potential Basis for Next-Generation Anticancer Therapy (IMAGE)

The Korea Advanced Institute of Science and Technology (KAIST)

KAIST Identifies a Molecular “Switch” That Activates Cell Growth Signaling, Suggesting a Potential Basis for Next-Generation Anticancer Therapy

Caption

Figure 1. Cryo-EM structure of the LARS1:IARS1 complex. (a) Domain organization of human LARS1 and IARS1. Regions not resolved in the cryo-EM map are indicated with white dotted boxes. CD, catalytic domain; CP, connective peptide; SC-fold, stem contact fold; ABD, anticodon-binding domain; UNE-L/UNE-I, domains unique appended to LARS1 and IARS1, respectively. (b) Cryo-EM map of the LARS1:IARS1 complex. Each domain is colored as in (a), and the overall architecture of the complex is shown from two orientations related by a 180° rotation.

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KAIST

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