A working model of CHD chromatin remodeler functions across cardiac developmental stages. (IMAGE)
Caption
A working model of CHD chromatin remodeler functions across cardiac developmental stages Schematic depicting the stage‑specific roles of key CHD family members during heart development. CHD7 acts primarily at early progenitor and outflow‑tract (OFT) stages, regulating enhancer activation and morphogenetic programs. CHD3/CHD4, as ATPase subunits of the NuRD complex, function during chamber specification and myocardial lineage maintenance. CHD8 emerges as a regulator of later ventricular growth and structural maturation. This temporal framework highlights the distinct, non‑redundant contributions of individual CHD remodelers to cardiac formation, from heart‑field specification through postnatal maturation, and underscores their links to congenital heart disease when disrupted.
Credit
World Journal of Pediatrics
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CC BY