Fig. 1 (IMAGE)

The University of Osaka

Fig. 1

Caption

PPP1R2 acts as a reversible thermosensor to regulate CLK1 phosphorylation and its localization to nuclear stress bodies (nSBs). As a result, nSBs regulate target pre-mRNA splicing in a temperature-dependent manner.

Credit

2026, Tsuyoshi Ueno et al., Thermo-Sensing Mechanisms of Splicing Control by Nuclear Stress Bodies, Molecular Cell

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