o SPOP ‘double-donut’ structure closes the loop on unexplained cancer mutations (IMAGE)

St. Jude Children's Research Hospital

o SPOP ‘double-donut’ structure closes the loop on unexplained cancer mutations

Caption

Published today in Molecular Cell, corresponding author Tanja Mittag, PhD, and co-first authors Matt Cuneo, PhD, and Mohamed-Raafet Ammar, PhD, St. Jude Department of Structural Biology, uncovered how a balance between active filament and inactive ‘double-donut’ states regulates SPOP function, and how key cancer-associated mutations disrupt this balance.

Credit

courtesy of St. Jude Children's Research Hospital

Usage Restrictions

none

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.