Revealing AML diversity that gene mutations alone could not capture (IMAGE)

Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University

Revealing AML diversity that gene mutations alone could not capture

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A research team led by Professor Seishi Ogawa (Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University; concurrently Principal Investigator at the Institute for the Advanced Study of Human Biology [WPI-ASHBi], Kyoto University), Assistant Professor Yotaro Ochi (same department), and Professor Sören Lehmann (Karolinska Institute) has carried out a large-scale epigenomic analysis of more than 1,500 AML patient samples. The team showed that AML can be classified into 16 subgroups based on its epigenomic features, each with its own molecular wiring, clinical prognosis, and drug sensitivity. The results reveal an additional dimension of AML diversity that cannot be captured by gene mutations alone.

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ASHBi/Kyoto University

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