Role of YAP/TAZ in the bone marrow (BM) niche and its activation for hematopoietic regeneration (IMAGE)

The Institute of Medical Science, The University of Tokyo

Role of YAP/TAZ in the bone marrow (BM) niche and its activation for hematopoietic regeneration

Caption

Researchers reveal that the transcription factors YAP and TAZ aid the regeneration of mesenchymal stromal cells and endothelial cells, thus restoring the BM niche. Notably, pharmacological activation of YAP/TAZ by GA-003 enhances BM niche reorganization and accelerates hematopoietic recovery after myeloablative therapies.

Credit

Prof. Atsushi Iwama from The University of Tokyo, Japan, and Dr. Taito Nishino from Nissan Chemical Corporation, Japan

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