Figure 1. Hippocampal astrocytes regulate memory persistence through Ankyrin-2 (Ank2)-dependent signaling pathways (IMAGE)
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Strong learning triggers an increase in brain-derived neurotrophic factor (BDNF) signaling several hours after learning. In response, astrocytes undergo structural changes and strengthen their physical interactions with nearby engram synapses that support memory. Ank2 plays a critical role in this process by regulating the stability and activity of IP3R2, a key protein involved in intracellular calcium signaling. When Ank2 is absent, astrocytic structural remodeling is disrupted and contact with engram synapses is reduced, preventing stable long-term memory maintenance. In contrast, activating astrocytic BDNF signaling using optogenetic stimulation was sufficient to prolong memory retention.
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Institute for Basic Science
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