Decoding tumor immunity: a four-step CIC-based subtyping strategy for precision immunotherapy. (IMAGE)

China Anti-Cancer Association

Decoding tumor immunity: a four-step CIC-based subtyping strategy for precision immunotherapy.

Caption

The current study was conducted in four major steps: (1) construction of cancer-immunity cycle (CIC)-related gene signatures and scoring the CIC activity in breast cancer patients; (2) classification of patients into CIC-based molecular subtypes according to the activity of six CIC steps; (3) validation of the predictive value of CIC subtypes in pan-cancer cohorts receiving Immune checkpoint inhibitor (ICI) therapy; and (4) multi-omic characterization to delineate subtype-specific immune, genomic, and metabolic features and identify potential therapeutic targets.

Credit

Cancer Biology & Medicine

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License

CC BY-NC

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