Receptor and chemicals (IMAGE)
Caption
In healthy people, binding of the molecule acetylcholine to its receptor (center, purple) on skeletal muscle cells triggers muscle contraction underlying regular daily activities. Heritable mutations in the receptor can cause defects in muscle acetylcholine receptor signaling that results in congenital muscle weakness. The chemicals shown include known drugs and experimental molecules investigated in the current study to correct the receptor defects.
Credit
Huanhuan Li, Hibbs Lab, UC San Diego.
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Must be used in conjunction with Nature paper on rare inherited muscle disorders
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Original content