Short-term responsiveness of DNA methylation–based aging biomarkers to a multimodal intervention comprising exercise and dietary guidance involving daily consumption of yogurt containing Bifidobacterium longum BB536: an exploratory randomized controlled (IMAGE)

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Short-term responsiveness of DNA methylation–based aging biomarkers to a multimodal intervention comprising exercise and dietary guidance involving daily consumption of yogurt containing Bifidobacterium longum BB536: an exploratory randomized controlled

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Figure 4. Exploratory analyses of DNAm-based surrogate biomarkers of GrimAge. Data are presented as adjusted mean value in DNAm-based surrogate biomarkers of GrimAge with 95% confidence intervals (CI) at post-intervention. Open and black circles represent an adjusted mean value in the CON and INT group, respectively. Scale bars show 95% CI. The dotted line indicates zero. Asterisks (*) indicate significant between-group differences by ANCOVA. Panels show; (A) DNAmCystatinC; (B) DNAmADM; (C) DNAmB2M; (D) DNAmGDF15; (E) DNAmLeptin; (F) DNAmPAI1; (G) DNAmTIMP1.

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Copyright: © 2026 Nishimura et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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