Phenylethanoid Glycosides: A Mini Review on their Anti-liver Injury Effects and Underlying Mechanisms (IMAGE)

Xia & He Publishing Inc.

Phenylethanoid Glycosides: A Mini Review on their Anti-liver Injury Effects and Underlying Mechanisms

Caption

Phenylethanoid glycosides (PhGs) are natural sugar‑containing compounds with diverse structures and broad pharmacological activities. This review summarizes their anti‑liver injury effects. Key compounds (acteoside, echinacoside, salidroside, forsythoside A) act through antioxidant (Nrf2), anti‑inflammatory (NF‑κB), anti‑apoptotic, and anti‑fibrotic (TGF‑β/Smad) pathways. Preclinical evidence is promising, but clinical translation is hindered by low bioavailability and complex metabolism. Future directions include structural optimization and gut microbiota studies.

Credit

Chang-Yun Wang, Shi-Jun Yue

Usage Restrictions

Credit must be given to the creator. Only noncommercial uses of the work are permitted.

License

CC BY-NC

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