The schematic diagram of MPDA/B@M in treating staphylococcus aureus infectious pneumonia. (IMAGE)

Tsinghua University Press

The schematic diagram of MPDA/B@M in treating staphylococcus aureus infectious pneumonia.

Caption

Under NIR irradiation, MPDA/B@M’s photothermal effect directly eradicates pathogens while upregulating HSP70 to enhance host inflammation tolerance. This synergizes with bufalin’s anti-inflammatory activity to remodel the immune microenvironment, reprogramming macrophages from pro-inflammatory M1 to anti-inflammatory M2 phenotypes. Ultimately achieving the goal of treating bacterial pneumonia.

Credit

Nano Research, Tsinghua University Press

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