Communication between T cells and fibroblasts drives progression of Sjögren disease (IMAGE)

Tokushima University

Communication between T cells and fibroblasts drives progression of Sjögren disease

Caption

Researchers reveal that in Sjögren disease, an autoimmune disease, not only immune cells but also the fibroblasts that make up the tissue are actively involved in the progression of the disease. CD153+ CD4+ T cells interact with CD30+ fibroblasts in primary Sjögren disease, amplifying inflammation and tissue damage. This pathological cellular interaction represents a potential therapeutic target for autoimmune Sjögren disease.

Credit

Professor Koji Yasutomo from Tokushima University, Japan

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