Long-lived CAR-T cells confer long-term degradation of TNF and sustained remission of RA (IMAGE)

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Long-lived CAR-T cells confer long-term degradation of TNF and sustained remission of RA

Caption

Schematic and experimental overview showing that TNFR1TIF CAR-T cells specifically bind, endocytose, and degrade soluble TNF via receptor-mediated endocytosis. A single intravenous infusion, without lymphodepleting preconditioning, reduces serum human TNF to near wild-type levels in hTNF-transgenic mice and provides sustained remission of rheumatoid arthritis equivalent in efficacy to repeated high-dose adalimumab treatment.

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hLife

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