hMPV M2-2 protein hijacks host splicing machinery for replication (IMAGE)

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hMPV M2-2 protein hijacks host splicing machinery for replication

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Researchers discovered that the human metapneumovirus (hMPV) M2-2 protein enters the nucleus and interacts with host RNA splicing factors, including hnRNP H1, hnRNP M, and hnRNP U. These interactions reprogram alternative splicing of key cellular genes such as STRAP and TANC2, creating a cellular environment that favors viral replication. The graphical model illustrates how hMPV exploits host mRNA processing pathways and identifies the M2-2–spliceosome interface as a potential antiviral therapeutic target.

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hLife

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