Proposed mechanism by which disruption of perineuronal nets (PNNs) in the deep cerebellar nuclei affects social behavior. (IMAGE)
Caption
In normal mice, neurons in the deep cerebellar nuclei are surrounded by PNNs and show robust neuronal activity during social interaction, allowing normal transmission of signals through cerebellum-linked neural circuits. In ASD-related mouse models and mice with experimentally disrupted PNNs, loss of PNNs is associated with increased ARNT2 expression and reduced neuronal activity. This reduction in cerebellar output is accompanied by decreased activity in downstream brain circuits and impaired social behavior.
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🄫 2026 K. Fujita
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