virus-delivering Salmonella_umass amherst (IMAGE)
Caption
In the system created by Forbes, the virus enters the cell from the virus-delivering Salmonella (VDS; 1). It then behaves as any normal virus would, implanting its own DNA into the nucleus of a cell, which holds the master plans of what proteins to make (2). Imagine that the nucleus is a photocopier and the virus sneaks in its own page, so that every time the nucleus “prints” proteins, viral proteins are created too. These viral proteins assemble into duplicate copies of the virus (3). These viruses cause the cancerous cell to split open and die (4). The virus particles then continue to infect neighboring cancer cells (5). Splitting the cancer cell also attracts immune cells (6), effectively training an antitumor immune response.
Credit
Shradha Khanduja, UMass Amherst
Usage Restrictions
Only to be used in describing the paper Salmonella vector creates de novo parvovirus that reduces solid tumors and forms antitumor immune memory
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Original content