Light-activated β-arrestin 1 forms condensates in cells (VIDEO)

Duke University

Caption

HEK293T cells engineered to produce a light-sensitive protein tag (Cry2-mCherry) fused to β-arrestin 1 were imaged after exposure to blue light. The light triggers the Cry2 component to cluster, drawing β-arrestin 1 together into visible droplet-like structures. Following stimulation, these condensates appear throughout the cell’s interior, demonstrating β-arrestin 1’s ability to organize into biomolecular condensates.

Credit

Rajagopal Lab

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