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Institute for Basic Science

Figure 1

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Protein deprivation triggers gut enterocytes to release the peptide CNMa, initiating gut–brain communication in Drosophila. This gut-brain signaling establishes a positive feedback loop that sustains neuronal activity and CNMa production. In addition, circulating CNMa modulates distinct brain neurons to promote essential amino acid intake while suppressing carbohydrate consumption.

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Institute for Basic Science

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