Neu5Gc-associated Serum Immunoglobulin G Glycosylation as a Diagnostic Biomarker for Hepatocellular Carcinoma (IMAGE)
Caption
Neu5Gc represents a promising biomarker for HCC diagnosis and therapy evaluation. Our dual strategy improves diagnostic sensitivity, and an N-glycosylation-related gene panel was identified for HCC differential diagnosis. Mechanistically, CMAH mutations induce alternative splicing and Neu5Gc synthesis, while metabolic reprogramming promotes sialic acid production. Together, exogenous Neu5Gc intake and endogenous metabolic changes form a feedback loop that promotes HCC progression. These results offer new insights for the development of diagnostic biomarkers and therapeutic targets in HCC.
Credit
Yue Pang, Chunwen Pu
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Credit must be given to the creator. Only noncommercial uses of the work are permitted.
License
CC BY-NC