The ability of HBNPs to target K. pneumoniae and antibacterial activity in vivo (IMAGE)

BMEF (BME Frontiers)

The ability of HBNPs to target K. pneumoniae and antibacterial activity in vivo

Caption

 In vivo distribution and targeting effect on K. pneumoniae of HBNPs/BSANPs. (A) Schematic diagram of the experimental procedure. (B and C) Live fluorescence images and fluorescence intensities of K. pneumoniae mice 0 to 8 h after injection of indocyanine green (ICG)–HBNP nanoparticles. (D and E) Live fluorescence images and fluorescence intensities of K. pneumoniae mice and normal mice 0 to 4 h after injection of PBS, ICG, ICG–HBNP, and ICG–BSANP nanoparticles. (F) Fluorescence images of major organs of K. pneumoniae mice and normal mice 4 h after injection of PBS, ICG, ICG–HBNP, and ICG–BSANP nanoparticles. (G and H) Fluorescence images and fluorescence intensities of the lungs of K. pneumoniae mice and normal mice 4 h after injection of ICG, ICG–HBNP, and ICG–BSANP nanoparticles. MFI, mean fluorescence intensity; ns, not significant.

Credit

Luo Lei Lab @ SWU-CPS.

Usage Restrictions

News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.