Azide-to-diazo transformation via Michael addition (IMAGE)

Tokyo University of Science

Azide-to-diazo transformation via Michael addition

Caption

2-Azidoacrylic acid esters are converted into phosphazide intermediates upon treatment with Amphos, followed by nucleophile-driven Michael addition. This transformation proceeds with concurrent nitrogen–nitrogen bond cleavage, affording β-heteroatom-substituted diazo esters efficiently under mild conditions.

Credit

Professor Suguru Yoshida from Tokyo University of Science, Japan Image source link: https://doi.org/10.1002/anie.4448961

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License

CC BY-NC

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