Advancements in Understanding the Role of Oxylipins in Liver Injury and Liver Failure (IMAGE)
Caption
While the immunoregulatory roles of oxylipins and their contributions to liver injury in ESLD are increasingly recognized, their cellular sources and precise mechanisms of action remain incompletely characterized. Significant challenges persist, including patient heterogeneity, insufficient mechanistic insight beyond macrophage-centric views, and technical limitations in lipidomic analyses. Future research must prioritize multi-cohort validation, detailed clinical subtyping, expanded immune cell analyses, and the integration of host–microbe metabolic interactions. Overcoming these hurdles will be essential for developing oxylipin-based therapeutic and preventive strategies for ESLD.
Credit
Zeyu Sun, Yu Shi
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License
CC BY-NC