Bone marrow fat-driven immune suppression and bone loss pathway (IMAGE)

Editorial Office of West China School of Stomatology, Sichuan University

Bone marrow fat-driven immune suppression and bone loss pathway

Caption

Schematic diagram illustrating how expansion of bone marrow adipocytes in obesity increases MCP-1 signaling, promotes PD-L1+ immunosuppressive myeloid cells, and enhances osteoclastogenesis, leading to bone loss.

Credit

Dr. Sergey Ryzhov and Dr. Clifford J. Rosen from MaineHealth Institute for Research, USA Image Source Link: https://doi.org/10.1038/s41413-026-00509-5

Usage Restrictions

Credit must be given to the creator.

License

CC BY

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